Micronized Isotretinoin is used in the treatment of severe, recalcitrant acne that does not respond to conventional therapies such as topical agents or oral antibiotics. The micronized formulation improves bioavailability at a lower dose, helping to reduce sebum production, inhibit acne-causing bacteria, normalize follicular keratinization, and decrease inflammation. This results in effective acne clearance with better tolerability and reduced dose-related side effects.