Amlodipine + Hydrochlorothiazide is primarily used in the treatment of hypertension (high blood pressure). Amlodipine relaxes and widens blood vessels, while Hydrochlorothiazide helps remove excess salt and water from the body. Together, they effectively lower blood pressure, reduce fluid overload, and decrease the risk of heart attack, stroke, and kidney complications associated with uncontrolled hypertension.