Progesterone (300 mg) SR progesterone tablet, such as Susten SR 300, is used for various conditions related to hormonal imbalance, including irregular periods, to help maintain a pregnancy by thickening the uterine lining, and as part of hormone replacement therapy (HRT) for menopausal symptoms to prevent uterine lining overgrowth. It can also help with premenstrual syndrome (PMS), endometriosis, and to support infertility treatments.