Metoprolol (25 mg) Extended-Release + Hydrochlorothiazide (12.5 mg) Tablet is a combination antihypertensive medication used to treat hypertension (high blood pressure) and reduce the risk of cardiovascular complications. Metoprolol, a selective beta-1 adrenergic blocker, slows the heart rate and reduces the heart's workload, while Hydrochlorothiazide, a thiazide diuretic, helps eliminate excess sodium and water from the body, lowering blood pressure. Together, they provide effective 24-hour blood pressure control and help reduce the risk of heart attack, stroke, heart failure, and kidney damage associated with uncontrolled hypertension.