Metoprolol (50 mg) Extended-Release + Hydrochlorothiazide (12.5 mg) Tablet is a combination antihypertensive medicine used to treat hypertension (high blood pressure) and reduce the risk of cardiovascular complications. Metoprolol, a selective beta-1 adrenergic blocker, decreases heart rate and reduces the heart's workload, while Hydrochlorothiazide, a thiazide diuretic, promotes the excretion of excess sodium and water from the body, helping to lower blood pressure. Together, they provide sustained 24-hour blood pressure control, improve cardiovascular health, and reduce the risk of heart attack, stroke, heart failure, and hypertension-related kidney damage.